Metformin- A Promising Agent for Chemoprevention in BRCA1 Carriers
نویسندگان
چکیده
3Molecular Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 4Genetics, The University of Texas MD Anderson Cancer Center, Houston, Texas 5Breast Cancer, The University of Texas MD Anderson Cancer Center, Houston, Texas 6Pathology, at the H. Lee Moffitt Cancer Center & Research Institute 7Oncological Sciences University of South Florida College of Medicine, Tampa Florida 8Breast Medical Oncology and Clinical Cancer Prevention, and Co-Director of Clinical Cancer Genetics, The University of Texas MD Anderson Cancer Center, Houston, Texas
منابع مشابه
Therapeutic targeting of BRCA1-mutated breast cancers with agents that activate DNA repair.
Cancers due to germline mutations in the BRCA1 gene tend to lack targets for approved chemoprevention agents. This study aimed at a targeted chemoprevention strategy for BRCA1-associated malignancies. Mutant BRCA1 limits the base-excision DNA repair activity that addresses oxidative DNA damage, the accumulation of which heightens one's risk for cancer. Therefore, we conducted a high-throughput ...
متن کاملPrevention and Epidemiology Therapeutic Targeting of BRCA1-Mutated Breast Cancers with Agents That Activate DNA Repair
Cancers due to germline mutations in the BRCA1 gene tend to lack targets for approved chemoprevention agents. This study aimed at a targeted chemoprevention strategy for BRCA1-associated malignancies. Mutant BRCA1 limits the base-excision DNA repair activity that addresses oxidative DNA damage, the accumulation of which heightens one's risk for cancer. Therefore, we conducted a high-throughput ...
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Options for the prevention of hereditary breast and ovarian cancer include screening, preventive surgery and chemoprevention. Screening studies with magnetic resonance imaging of the breast are promising but the technology is not widespread and MRI is unlikely to be available as a screening tool in the near future. Prophylactic oophorectomy and mastectomy are effective preventive measures and a...
متن کاملGermline BRCA1 mutation reprograms breast epithelial cell metabolism towards mitochondrial-dependent biosynthesis: evidence for metformin-based “starvation” strategies in BRCA1 carriers
We hypothesized that women inheriting one germline mutation of the BRCA1 gene ("one-hit") undergo cell-type-specific metabolic reprogramming that supports the high biosynthetic requirements of breast epithelial cells to progress to a fully malignant phenotype. Targeted metabolomic analysis was performed in isogenic pairs of nontumorigenic human breast epithelial cells in which the knock-in of 1...
متن کاملRisk factors and risk reduction of breast and ovarian cancer.
PURPOSE OF REVIEW Breast and ovarian cancer remain a significant burden for women living in the Western world. This paper reviews the risk factors and current strategies to prevent these diseases. RECENT FINDINGS Established factors associated with the risk of breast cancer include family history, reproductive factors and lactation, as well as age at menarche and menopause. Hormone replacemen...
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عنوان ژورنال:
دوره 1 شماره
صفحات -
تاریخ انتشار 2012